GPR62 Antibody - #DF2756
| 製品: | GPR62 Antibody |
| カタログ: | DF2756 |
| タンパク質の説明: | Rabbit polyclonal antibody to GPR62 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Horse |
| 分子量: | 38 kDa; 38kD(Calculated). |
| ユニプロット: | Q9BZJ7 |
| RRID: | AB_2839962 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2756, RRID:AB_2839962.
折りたたみ／展開
G protein coupled receptor GPCR8; G protein coupled receptor KPG_005; G protein-coupled receptor 62; G-protein coupled receptor GPCR8; G-protein coupled receptor KPG_005; GPCR8; GPR62; GPR62_HUMAN; hGPCR8; KPG_005; MGC26943; Probable G protein coupled receptor 62; Probable G-protein coupled receptor 62;
免疫原
A synthesized peptide derived from human GPR62, corresponding to a region within C-terminal amino acids.
Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
- Q9BZJ7 GPR62_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization.
Cell membrane>Multi-pass membrane protein. Endosome membrane>Multi-pass membrane protein.
Note: Colocalizes with ARRB2 in the endosome (PubMed:28827538).
Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.
Belongs to the G-protein coupled receptor 1 family.
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