FGF19 Antibody - #DF2651

FIGURE 6 EPC ameliorated MAFLD formation in rats by regulating BA metabolism. (A–G) Relative expression of CYP7A1, FXR, CYP27A1, BSEP, CYP7B1, CYP8B1, NTCP mRNA in liver, n = 6; (H–L) Relative expression of protein CYP7A1, FXR, SHP, p-AMPK, and p-ERK in the liver, n = 4; (M–N) Relative expression of protein FXR and FGF15 in the ileum, n = 4. (O–P) Representative immunoblotting images of CYP7A1, FXR, SHP, p-AMPK,and p-ERK in the liver. (Q) Representative immunoblotting images of FXR and FGF15 in the ileum. Data are presented as mean ± SEM. One-way analysis of variance (ANOVA) was conducted for the group comparison. *p < 0.05, **p < 0.01, ***p < 0.001 vs. MOD group. CYP7A1, cholesterol 7α-hydroxylase; FXR, farnesoid X receptor; CYP27A1, sterol 27-hydroxylase; BSEP, bile salt export protein; CYP7B1, oxysterol 7α-hydroxylase; CYP8B1, sterol 12αhydroxylase; NTCP, Na + -taurocholate co-transporting polypeptides; SHP, small heterodimer partner; AMPK, 5’-AMP-activated protein kinase; ERK, Extracellular signal-regulated kinase.

Fig. 5 Expression of FGF19 of the terminal ileum in chronic diar- rhoea patients. a, b A positive immunoperoxidase reaction was observed in the cytoplasmatic compartment of terminal ileum mucosa epithelial cells, and some gland cells in the lamina propria. Ileum enterocytes showed FGF19 signal from apical to basal domains, espe-cially in the apical domains. c, d The staining intensity was divided into 2 categories (c pale brown = 1; d brown = 2). e–g The percentage of immunoreactive cells were calculated and classified on a 3-point scale (e 1–33% = 1; f 34–66% = 2; g 67–100% = 3)

Fig. 5| Expression of FGF19 of the terminal ileum in chronic diarrhoea patients. a, b A positive immunoperoxidase reaction was observed in the cytoplasmatic compartment of terminal ileum mucosa epithelial cells, and some gland cells in the lamina propria. Ileum enterocytes showed FGF19 signal from apical to basal domains, especially in the apical domains.