| 製品: | ALKBH4 Antibody |
| カタログ: | DF2584 |
| タンパク質の説明: | Rabbit polyclonal antibody to ALKBH4 |
| アプリケーション: | IHC IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 36 kDa(Observed); 34kD(Calculated). |
| ユニプロット: | Q9NXW9 |
| RRID: | AB_2839790 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2584, RRID:AB_2839790.
折りたたみ／展開
2010004B12Rik; ABH4; Abj4; AlkB, alkylation repair homolog 4 (E. coli); Alkylated DNA repair protein alkB homolog 4; FLJ20013; Probable alpha-ketoglutarate dependent dioxygenase ABH4; RGD1308608;
免疫原
A synthesized peptide derived from human ALKBH4, corresponding to a region within the internal amino acids.
- Q9NXW9 ALKB4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAAETPEVLRECGCKGIRTCLICERQRGSDPPWELPPAKTYRFIYCSDTGWAVGTEESDFEGWAFPFPGVMLIEDFVTREEEAELVRLMDRDPWKLSQSGRRKQDYGPKVNFRKQKLKTEGFCGLPSFSREVVRRMGLYPGLEGFRPVEQCNLDYCPERGSAIDPHLDDAWLWGERLVSLNLLSPTVLSMCREAPGSLLLCSAPSAAPEALVDSVIAPSRSVLCQEVEVAIPLPARSLLVLTGAARHQWKHAIHRRHIEARRVCVTFRELSAEFGPGGRQQELGQELLRIALSFQGRPV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).
Cytoplasm. Nucleus. Nucleus>Nucleolus. Midbody.
Note: Associates with the contractile ring and midbody.
Widely expressed, with highest expression in pancreas, ovary and spleen.
Belongs to the alkB family.
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