CD11c Antibody - #DF2542

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製品: CD11c Antibody
カタログ: DF2542
タンパク質の説明: Rabbit polyclonal antibody to CD11c
アプリケーション: WB IHC
Cited expt.: WB
反応性: Human, Rat
分子量: 150 kDa; 128kD(Calculated).
ユニプロット: P20702
RRID: AB_2839748

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
クローナリティ:
Polyclonal
特異性:
CD11c Antibody detects endogenous levels of total CD11c.
RRID:
AB_2839748
引用形式: Affinity Biosciences Cat# DF2542, RRID:AB_2839748.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

95 alpha chain; 95; CD 11c; CD11 antigen like family member C; CD11 antigen-like family member C; CD11c; CD11c antigen; Complement component 3 receptor 4 subunit; CR4; Integrin alpha X; Integrin alpha X chain; Integrin alpha-X; Integrin aX; Integrin subunit alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit; ITAX_HUMAN; ITGAX; LEU M5 alpha subunit; Leu M5; Leukocyte adhesion glycoprotein p150 95 alpha chain; Leukocyte adhesion glycoprotein p150; Leukocyte adhesion receptor p150 95; Leukocyte adhesion receptor p150; Leukocyte surface antigen p150 95 alpha subunit; Leukocyte surface antigen p150 alpha subunit; Myeloid membrane antigen alpha subunit; p150 95 integrin alpha chain; p150; p150/95; SLEB6;

免疫原

免疫原:

A synthesized peptide derived from human CD11c, corresponding to a region within the internal amino acids.

Uniprot:

P20702(ITAX_HUMAN) >>Visit HPA database.

遺伝子(ID):
ITGAX(3687)
発現特異性:
P20702 ITAX_HUMAN:

Predominantly expressed in monocytes and granulocytes.

タンパク質の説明:
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
タンパク質配列:
MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANGQIAPENGTQTPSPPSEK

研究背景

機能:

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Predominantly expressed in monocytes and granulocytes.

タンパク質ファミリー:

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Belongs to the integrin alpha chain family.

研究領域

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

参考文献

1). Norcholic Acid Promotes M1 Macrophage Polarization in Acute Pancreatitis by Activating the Wnt/β-Catenin Pathway. Frontiers in bioscience (Landmark edition), 2025 (PubMed: 40613297) [IF=3.3]

Application: WB    Species: human    Sample:

Fig. 2. NorCA enhances LPS-induced M1 macrophage polarization. (a) Flow cytometric analysis quantified CD86/CD11c expression in LPS and LPS + NorCA groups. (b,c) Flow cytometry-derived CD86/CD11c expression in LPS vs LPS + NorCA groups (bar graphs). (d,e) qRT-PCR analysis quantified CD86/CD11c expression in LPS vs LPS + NorCA groups. (f–h) The expression levels of CD86 and CD11c in the LPS group and LPS + NorCA group were detected by western blotting. *p < 0.05, **p < 0.01, ***p < 0.001. LPS, lipopolysaccharide; qRT-PCR, quantitative reverse transcription PCR; FITC-A, fluorescein isothiocyanate - area; FSC-A, forward scatter - area.

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