GBP2 Antibody - #DF2499
| 製品: | GBP2 Antibody |
| カタログ: | DF2499 |
| タンパク質の説明: | Rabbit polyclonal antibody to GBP2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 分子量: | 67 kDa; 67kD(Calculated). |
| ユニプロット: | P32456 |
| RRID: | AB_2839705 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2499, RRID:AB_2839705.
折りたたみ／展開
GBP 2; GTP binding protein 2; Guanine nucleotide binding protein 2; Guanylate binding protein 2 interferon inducible; HuGBP 2; HuGBP2; Interferon induced guanylate binding protein 2;
免疫原
- P32456 GBP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
PTMs - P32456 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S52 | Phosphorylation | Uniprot | |
| K242 | Acetylation | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| Y333 | Phosphorylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| K483 | Acetylation | Uniprot | |
| K485 | Acetylation | Uniprot | |
| K501 | Acetylation | Uniprot |
研究背景
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
Isoprenylation is required for proper subcellular location.
Cytoplasm. Cytoplasm>Perinuclear region. Golgi apparatus membrane. Membrane>Lipid-anchor.
Note: GBP2-GBP5 dimers localize to the Golgi apparatus.
Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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