Cystatin A Antibody - #DF7458

(2)  
製品: Cystatin A Antibody
カタログ: DF7458
タンパク質の説明: Rabbit polyclonal antibody to Cystatin A
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
予測: Pig, Bovine, Horse, Sheep, Dog
分子量: 11kDa; 11kD(Calculated).
ユニプロット: P01040
RRID: AB_2839395

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(92%), Bovine(83%), Horse(82%), Sheep(92%), Dog(83%)
クローナリティ:
Polyclonal
特異性:
Cystatin A Antibody detects endogenous levels of total Cystatin A.
RRID:
AB_2839395
引用形式: Affinity Biosciences Cat# DF7458, RRID:AB_2839395.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

AREI; cstA; Cystatin A; Cystatin AS; Cystatin-A; Cystatin-AS; CYTA_HUMAN; Stefin A; Stefin-A; STF1; STFA;

免疫原

免疫原:

A synthesized peptide derived from human Cystatin A, corresponding to a region within C-terminal amino acids.

Uniprot:

P01040(CYTA_HUMAN) >>Visit HPA database.

遺伝子(ID):
CSTA(1475)
発現特異性:
P01040 CYTA_HUMAN:

Expressed in the skin throughout the epidermis.

タンパク質の説明:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
タンパク質配列:
MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
92
Sheep
92
Bovine
83
Dog
83
Horse
82
Rabbit
73
Chicken
55
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.

細胞の位置付け:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in the skin throughout the epidermis.

タンパク質ファミリー:

Belongs to the cystatin family.

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