製品: MUNC-18a Antibody
カタログ: DF7336
タンパク質の説明: Rabbit polyclonal antibody to MUNC-18a
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Rabbit
分子量: 67kDa; 68kD(Calculated).
ユニプロット: P61764
RRID: AB_2839274

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Rabbit(100%)
クローナリティ:
Polyclonal
特異性:
MUNC-18a Antibody detects endogenous levels of total MUNC-18a.
RRID:
AB_2839274
引用形式: Affinity Biosciences Cat# DF7336, RRID:AB_2839274.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

FLJ37475 antibody;Munc 18 1 antibody;Munc 18a antibody;MUNC18 1 antibody;N-Sec1 antibody;Neuronal SEC1 antibody;NSec1 antibody;p67 antibody;Protein unc-18 homolog 1 antibody;Protein unc-18 homolog A antibody;Rb sec1 antibody;RBSEC1 antibody;STXB1_HUMAN antibody;STXBP1 antibody;Syntaxin binding protein 1 antibody;Syntaxin-binding protein 1 antibody;Unc 18 homolog antibody;Unc 18A antibody;Unc-18A antibody;Unc18 1 antibody;UNC18 antibody;Unc18-1 antibody;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P61764 STXB1_HUMAN:

Brain and spinal cord. Highly enriched in axons.

タンパク質の説明:
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
タンパク質配列:
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Pig
0
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P61764 基板として

Site PTM Type Enzyme
K7 Ubiquitination
K13 Ubiquitination
S70 Phosphorylation
K92 Ubiquitination
Y145 Phosphorylation
K184 Ubiquitination
K196 Ubiquitination
K208 Ubiquitination
K294 Ubiquitination
S306 Phosphorylation
K308 Ubiquitination
S313 Phosphorylation
K314 Ubiquitination
K321 Methylation
K321 Ubiquitination
K332 Ubiquitination
K333 Ubiquitination
Y337 Phosphorylation
K339 Ubiquitination
K364 Ubiquitination
T376 Phosphorylation
K382 Ubiquitination
S454 Phosphorylation
T455 Phosphorylation
Y473 Phosphorylation
T479 Phosphorylation Q13627 (DYRK1A)
T489 Phosphorylation
S507 Phosphorylation
S509 Phosphorylation
S516 Phosphorylation
Y531 Phosphorylation
T574 Phosphorylation
K587 Ubiquitination
S593 Phosphorylation
S594 Phosphorylation

研究背景

機能:

Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

細胞の位置付け:

Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Brain and spinal cord. Highly enriched in axons.

サブユニット構造:

Interacts with SYTL4 (By similarity). Interacts with STX1A. Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation. Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity).

タンパク質ファミリー:

Belongs to the STXBP/unc-18/SEC1 family.

研究領域

· Organismal Systems > Nervous system > Synaptic vesicle cycle.

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