| 製品: | HDGF Antibody |
| カタログ: | DF7289 |
| タンパク質の説明: | Rabbit polyclonal antibody to HDGF |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 分子量: | 26kDa(Observed); 27kD(Calculated). |
| ユニプロット: | P51858 |
| RRID: | AB_2839228 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7289, RRID:AB_2839228.
折りたたみ／展開
FLJ96580; HDGF; HDGF_HUMAN; Hepatoma derived growth factor; Hepatoma-derived growth factor; High mobility group protein 1 like 2; High mobility group protein 1-like 2; HMG-1L2; HMG1L2;
免疫原
A synthesized peptide derived from human HDGF, corresponding to a region within the internal amino acids.
- P51858 HDGF_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL
研究背景
Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein.
Does not have mitogenic activity for fibroblasts. Does not bind heparin.
Has mitogenic activity for fibroblasts. Heparin-binding protein.
Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.
Phosphorylation at Ser-165 is likely to be required for secretion.
Nucleus. Cytoplasm. Secreted>Extracellular exosome.
Note: Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).
Nucleus. Cytoplasm. Secreted>Extracellular exosome.
Note: Secreted by exosomes and is located on the outer exosome surface.
Nucleus. Cytoplasm. Secreted>Extracellular exosome.
Note: Secreted by exosomes and is located on the outer exosome surface.
Ubiquitous.
The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.
The N-terminal region does not contain a typical signal sequence but is required for secretion (By similarity). It also determines exosomal location (PubMed:26845719).
Belongs to the HDGF family.
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