SLC16A4 Antibody - #DF7145

Figure 3. GD-A effectively inhibits lactic acid efflux in vitro and reverses the pH gradient. A) Cellular mechanism by which GD-A NPs inhibit lactate efflux and enhance tumor acidosis. B-C) Green fluorescence images of intracellular H₂S generation in H22 cells following co-incubation with PBS, As3+, As5+,Zn2+,GYY4137, DCF, GD NPs, and GD-A NPs, along with corresponding fluorescence intensity analysis (n=3), scale bar:50 μm. D) CLSM images of mitochondrial membrane potential fluorescence probes in H22 cells co-incubated with PBS, As³⁺, As⁵⁺, GD NPs, and GD-A NPs for 6 h, scale bar: 20 μm. E) Representative western blots of different protein levels in H22 cells after treatment with different groups. FG) Analysis of intracellular and extracellular lactate levels in H22 cells after 24 h of treatment under different conditions (n=3). H-I) Changes in intracellular pH in H22 cells after co-culture under different treatment conditions, along with the corresponding fluorescence quantification. scale bar: 50 μm.Results are expressed as mean ± SD; differences from the control group are denoted by * p