KLK5 Antibody - #DF7137

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製品: KLK5 Antibody
カタログ: DF7137
タンパク質の説明: Rabbit polyclonal antibody to KLK5
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 32kDa; 32kD(Calculated).
ユニプロット: Q9Y337
RRID: AB_2839091

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:100-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(80%), Bovine(90%), Horse(80%), Sheep(90%), Rabbit(100%), Dog(90%)
クローナリティ:
Polyclonal
特異性:
KLK5 Antibody detects endogenous levels of total KLK5.
RRID:
AB_2839091
引用形式: Affinity Biosciences Cat# DF7137, RRID:AB_2839091.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

HK5; Kallikrein 5; Kallikrein L2; Kallikrein like 2; Kallikrein like protein 2; Kallikrein related peptidase 5; Kallikrein-5; Kallikrein-like protein 2; Kallikrein5; KLK 5; KLK L2; KLK-L2; KLK5; KLK5_HUMAN; KLKL 2; KLKL2; SCTE; Stratum corneum tryptic enzyme; UNQ570/PRO1132;

免疫原

免疫原:

A synthesized peptide derived from human KLK5, corresponding to a region within the internal amino acids.

Uniprot:

Q9Y337(KLK5_HUMAN) >>Visit HPA database.

遺伝子(ID):
KLK5(25818)
発現特異性:
Q9Y337 KLK5_HUMAN:

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

タンパク質の説明:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
タンパク質配列:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Bovine
90
Sheep
90
Dog
90
Pig
80
Horse
80
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

May be involved in desquamation.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.

タンパク質ファミリー:

Belongs to the peptidase S1 family. Kallikrein subfamily.

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