(1)
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6994, RRID:AB_2838950.
折りたたみ／展開
Lamina associated polypeptide 2; LAP 2; LEM domain containing 4; LEMD4; Thymopoietin; Thymopoietin isoform alpha; Thymopoietin related peptide isoform alpha; Thymopoietin related peptide isoforms beta/gamma; Thymopoietin, isoforms beta/gamma; TMPO; TP alpha; TP; TP beta/gamma; TPRP isoform alpha; TPRP isoforms beta/gamma;
免疫原
A synthesized peptide derived from human TMPO, corresponding to a region within the internal amino acids.
- P42167 LAP2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.
Citrullinated by PADI4.
Nucleus inner membrane>Single-pass type II membrane protein.
Note: Tightly associated with the nuclear lamina.
Cytoplasm.
Expressed in many tissues. Most abundant in adult thymus and fetal liver.
Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
Belongs to the LEM family.
参考文献
Application: WB Species: Mouse Sample: fibroblasts
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