MSMB Antibody - #DF6720

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製品: MSMB Antibody
カタログ: DF6720
タンパク質の説明: Rabbit polyclonal antibody to MSMB
アプリケーション: WB IHC
Cited expt.: WB
反応性: Human, Mouse
分子量: 13kDa; 13kD(Calculated).
ユニプロット: P08118
RRID: AB_2838682

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
MSMB Antibody detects endogenous levels of total MSMB.
RRID:
AB_2838682
引用形式: Affinity Biosciences Cat# DF6720, RRID:AB_2838682.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Beta microseminoprotein [Precursor]; Beta-microseminoprotein; HPC 13; HPC13; IGBF; Immunoglobulin binding factor; Immunoglobulin-binding factor; microseminoprotein beta; Msmb; MSMB_HUMAN; MSP; MSPB; PN 44; PN44; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids; Prostate secretory protein PSP94; PRPS; PRSP; PSP 57; PSP; PSP-94; PSP57; PSP94; Seminal plasma beta inhibin; Seminal plasma beta-inhibin;

免疫原

免疫原:

A synthesized peptide derived from human MSMB, corresponding to a region within the internal amino acids.

Uniprot:

P08118(MSMB_HUMAN) >>Visit HPA database.

遺伝子(ID):
MSMB(4477)
発現特異性:
P08118 MSMB_HUMAN:

Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.

タンパク質の説明:
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.
タンパク質配列:
MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII

研究背景

細胞の位置付け:

Secreted.
Note: Sperm surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.

タンパク質ファミリー:

Belongs to the beta-microseminoprotein family.

参考文献

1). Identification and validation of MSMB as a critical gene for prostate cancer development in obese people. American journal of cancer research, 2023 (PubMed: 37168344) [IF=3.6]

Application: WB    Species: human    Sample:

Figure 4. MSMB downregulated in obese PCA patients and influence PCA cells proliferation. The mRNA (A) and protein (B) level of MSMB between PCA tumor tissues and adjacent normal tissues in obese PCA patients. (C, D) The protein level of MSMB in two types of PCA cell lines: PC-3 (C) and DU145 (D) after PCA cells transfected by oeMSMB plasmids or not. Cell proliferation of PC-3 (E) and DU145 (F) was detected after cells transfected by oeControl and oeMSMB plasmids. *represents P < 0.05. **represents P < 0.01. The RT-qPCR and Western blot used GAPDH as endogenous control. N: normal tissues, T: tumor tissues.

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