ORM1 Antibody - #DF6623

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製品: ORM1 Antibody
カタログ: DF6623
タンパク質の説明: Rabbit polyclonal antibody to ORM1
アプリケーション: WB IHC
反応性: Human, Mouse
分子量: 24kDa, 35-43kDa(Glycosylated)(Observed); 24kD(Calculated).
ユニプロット: P02763
RRID: AB_2838585

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#DF6623-BP

ORM1 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
ORM1 Antibody detects endogenous levels of total ORM1.
RRID:
AB_2838585
引用形式: Affinity Biosciences Cat# DF6623, RRID:AB_2838585.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

A1AG1_HUMAN; AGP 1; AGP A; AGP; AGP1; Alpha 1 acid glycoprotein; Alpha-1-acid glycoprotein 1; alpha-1-AGP; Epididymis secretory sperm binding protein Li 153w; glycoprotein, alpha-1-acid, of serum; HEL S 153w; OMD 1; ORM; ORM1; Orosomucoid 1; Orosomucoid-1;

免疫原

免疫原:

A synthesized peptide derived from human ORM1, corresponding to a region within the internal amino acids.

Uniprot:

P02763(A1AG1_HUMAN) >>Visit HPA database.

遺伝子(ID):
ORM1(5004)
発現特異性:
P02763 A1AG1_HUMAN:

Expressed by the liver and secreted in plasma.

タンパク質の説明:
Alpha-1-acid glycoprotein 1 (AGP1), also called orosomucoid-1 (ORM1), is a glycoprotein synthesized mostly by hepatocytes and present in human plasma. ORM1 is an acute-phase reactant protein controlled by glucocorticoids, interleukin-1 and interleukin-6, and increase up to 5-50 times upon infection and/or inflammation. Anti-apoptotic effect and role as immunomodulator of ORM have been reported. ORM is an important carrier for synthetic drugs and influences their distribution and availability in the body. This antibody recognizes a band about 44 kDa in human plasma which may be due to the glycosylation of ORM1 or the dimer formation of the protein.
タンパク質配列:
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES

研究背景

機能:

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

PTMs:

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed by the liver and secreted in plasma.

タンパク質ファミリー:

Contains a beta-barrel that binds various ligands in its interior.

Belongs to the calycin superfamily. Lipocalin family.

参考文献

1). iTRAQ based proteomic analysis of PM2.5 induced lung damage. RSC Advances, 2019 (PubMed: 35517034) [IF=3.9]

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