SCGB1A1 Antibody - #DF6581

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製品: SCGB1A1 Antibody
カタログ: DF6581
タンパク質の説明: Rabbit polyclonal antibody to SCGB1A1
アプリケーション: WB IHC IF/ICC
Cited expt.: WB
反応性: Human, Mouse, Rat
分子量: 10kDa(Observed); 10kD(Calculated).
ユニプロット: P11684
RRID: AB_2838543

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#DF6581-BP

SCGB1A1 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
SCGB1A1 Antibody detects endogenous levels of total SCGB1A1.
RRID:
AB_2838543
引用形式: Affinity Biosciences Cat# DF6581, RRID:AB_2838543.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; Clara cell specific 10 kD protein; Clara cells 10 kDa secretory protein; OTTHUMP00000236107; SCGB1A1; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Urinary protein 1; Urine protein 1; UTER_HUMAN; Uteroglobin;

免疫原

免疫原:

A synthesized peptide derived from human SCGB1A1, corresponding to a region within the internal amino acids.

Uniprot:

P11684(UTER_HUMAN) >>Visit HPA database.

遺伝子(ID):
SCGB1A1(7356)
発現特異性:
P11684 UTER_HUMAN:

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

タンパク質の説明:
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
タンパク質配列:
MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN

研究背景

機能:

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

タンパク質ファミリー:

Belongs to the secretoglobin family.

参考文献

1). SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC. Oncology letters, 2024 (PubMed: 39268163) [IF=2.5]

Application: WB    Species: human    Sample:

Figure 5. - Survival analysis and expression characteristics of SCGB1A1. (A) Overall survival analysis of ABCA8. (B) Overall survival analysis of SCGB1A1. (C) Disease-free survival analysis of ABCA8. (D) Disease-free survival analysis of SCGB1A1. (E) ABCA8, (F) SCGB1A1, and (G) CTSC expression levels in the clinical samples. (H) Immunohistochemical staining of SCGB1A1 in the clinical sample. Representative SCGB1A1+ cells are marked with blue arrows. Scale bar, 50 µm. (I) Statistical analysis of SCGB1A1+ cells after immunohistochemical staining. (J) The knockdown of SCGB1A1 expression following Lv-SCGB1A1 transduction. The viability of Lv-SCGB1A1-infected and Lv-Control-infected CAL27 cells were determined using a Cell Counting Kit-8 assay. (K) Analysis of SCGB1A1 expression levels in the pan-cancerous tissue. **P
2). The traditional Chinese patented medicine Qingke Pingchuan granules alleviate acute lung injury by regenerating club cells. Pulmonary circulation, 2022 (PubMed: 36186720) [IF=2.2]

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