SAA1/2 Antibody - #DF6533

(1)  
製品: SAA1/2 Antibody
カタログ: DF6533
タンパク質の説明: Rabbit polyclonal antibody to SAA1/2
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Bovine, Horse, Sheep, Rabbit, Dog
分子量: 14kDa; 14kD(Calculated).
ユニプロット: P0DJI8 | P0DJI9
RRID: AB_2838495

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Bovine(92%), Horse(92%), Sheep(92%), Rabbit(92%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
SAA1/2 Antibody detects endogenous levels of total SAA1/2.
RRID:
AB_2838495
引用形式: Affinity Biosciences Cat# DF6533, RRID:AB_2838495.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

PIG4; SAA; SAA1; SAA2; Serum amyloid A 2 protein; Serum amyloid A protein; Serum amyloid A1; Serum amyloid A2; TP53I4; Tumor protein p53 inducible protein 4;

免疫原

免疫原:

A synthesized peptide derived from human SAA1/2, corresponding to a region within the internal amino acids.

Uniprot:

P0DJI8(SAA1_HUMAN) >>Visit HPA database.

P0DJI9(SAA2_HUMAN) >>Visit HPA database.

遺伝子(ID):
SAA1(6288) | SAA2(6289)
発現特異性:
P0DJI8 SAA1_HUMAN:

Expressed by the liver; secreted in plasma (at protein level).

P0DJI9 SAA2_HUMAN:

Expressed by the liver; secreted in plasma.

タンパク質の説明:
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
タンパク質配列:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY

MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISNARENIQRLTGRGAEDSLADQAANKWGRSGRDPNHFRPAGLPEKY

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
100
Horse
92
Bovine
92
Sheep
92
Rabbit
92
Pig
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Major acute phase protein.

PTMs:

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed by the liver; secreted in plasma (at protein level).

タンパク質ファミリー:

Belongs to the SAA family.

機能:

Major acute phase reactant. Apolipoprotein of the HDL complex.

PTMs:

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed by the liver; secreted in plasma.

タンパク質ファミリー:

Belongs to the SAA family.

参考文献

1). Fusobacterium nucleatum extracellular vesicles are enriched in colorectal cancer and facilitate bacterial adhesion. Science advances, 2024 (PubMed: 39303027) [IF=11.7]

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