CRP Antibody - #DF6027

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製品: CRP Antibody
カタログ: DF6027
タンパク質の説明: Rabbit polyclonal antibody to CRP
アプリケーション: WB IHC IF/ICC
Cited expt.: WB
反応性: Human, Mouse, Rat, Monkey
予測: Rabbit
分子量: 25kDa; 25kD(Calculated).
ユニプロット: P02741
RRID: AB_2838002

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat,Monkey
予測:
Rabbit(89%)
クローナリティ:
Polyclonal
特異性:
CRP Antibody detects endogenous levels of total CRP.
RRID:
AB_2838002
引用形式: Affinity Biosciences Cat# DF6027, RRID:AB_2838002.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Pentraxin 1, short; C reactive protein; C reactive protein pentraxin related; C-reactive protein(1-205); CRP; CRP_HUMAN; MGC88244; Pentraxin 1; PTX 1; PTX1;

免疫原

免疫原:

A synthesized peptide derived from human CRP, corresponding to a region within the internal amino acids.

Uniprot:

P02741(CRP_HUMAN) >>Visit HPA database.

遺伝子(ID):
CRP(1401)
発現特異性:
P02741 CRP_HUMAN:

Found in plasma.

タンパク質の説明:
Human c-Reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosynthesis (5).
タンパク質配列:
MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
89
Pig
0
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Found in plasma.

タンパク質ファミリー:

Belongs to the pentraxin family.

参考文献

1). Low-Frequency Vibration Promotes Tumor Necrosis Factor-α Production to Increase Cartilage Degeneration in Knee Osteoarthritis. Cartilage, 2021 (PubMed: 32532183) [IF=2.7]

Application: WB    Species: mouse    Sample: cartilage

Figure 3.| Expression of FAH, TIM2, and CRP in the cartilage in 4 groups. Expression of FAH, TIM2, and CRP in the cartilage was detected in different groups. FAH = fumarylacetoacetase hydrolase; TIM2 = tissue inhibitor of metalloproteinases 2; CRP =C-reactive protein; WBV = whole-body vibration; TNF-α = tumor necrosis factor-α; DMM = destabilization medial meniscus.

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