ATRIP Antibody - #AF5417
| 製品: | ATRIP Antibody |
| カタログ: | AF5417 |
| タンパク質の説明: | Rabbit polyclonal antibody to ATRIP |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Sheep, Rabbit |
| 分子量: | 85 kDa; 86kD(Calculated). |
| ユニプロット: | Q8WXE1 |
| RRID: | AB_2837901 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF5417, RRID:AB_2837901.
折りたたみ／展開
AGS1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; DKFZp762J2115; FLJ12343; MGC20625; MGC21482; MGC26740;
免疫原
- Q8WXE1 ATRIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDLEELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8WXE1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S9 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| K32 | Acetylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Q13535 (ATR) | Uniprot |
| S72 | Phosphorylation | Q13535 (ATR) | Uniprot |
| K96 | Ubiquitination | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S239 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K270 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| T307 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| T523 | Phosphorylation | Uniprot | |
| Y636 | Phosphorylation | Uniprot |
研究背景
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Phosphorylated by ATR.
Nucleus.
Note: Redistributes to discrete nuclear foci upon DNA damage.
Ubiquitous.
Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.
The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
Belongs to the ATRIP family.
研究領域
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
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