Annexin III Antibody - #AF5159

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製品: Annexin III Antibody
カタログ: AF5159
タンパク質の説明: Rabbit polyclonal antibody to Annexin III
アプリケーション: WB IHC IF/ICC
Cited expt.: IHC
反応性: Human, Mouse, Rat
予測: Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 36 kDa(Observed); 36kD(Calculated).
ユニプロット: P12429
RRID: AB_2837645

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#AF5159-BP

Annexin III Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
予測:
Bovine(100%), Horse(%), Sheep(%), Rabbit(%), Dog(%), Xenopus(%)
クローナリティ:
Polyclonal
特異性:
Annexin III Antibody detects endogenous levels of total Annexin III.
RRID:
AB_2837645
引用形式: Affinity Biosciences Cat# AF5159, RRID:AB_2837645.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

2-cyclic phosphate 2-phosphohydrolase; 35-alpha calcimedin; Annexin A3; Annexin III; Annexin-3; ANX3; ANXA 3; Anxa3; ANXA3_HUMAN; Calcimedin 35 alpha; Inositol 1 2 cyclic phosphate 2 phosphohydrolase; Inositol 1; Lipocortin III; OTTHUMP00000160701; OTTHUMP00000219237; OTTHUMP00000219238; PAP III; PAP-III; Placental anticoagulant protein III;

免疫原

免疫原:

A synthesized peptide derived from human Annexin III, corresponding to a region within N-terminal amino acids.

Uniprot:

P12429(ANXA3_HUMAN) >>Visit HPA database.

遺伝子(ID):
ANXA3(306)
タンパク質の説明:
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
タンパク質配列:
MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Horse
90
Pig
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

タンパク質ファミリー:

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Belongs to the annexin family.

参考文献

1). Psoralen alleviates ulcerative colitis by suppressing inflammation, modulating oxidative stress, and regulating ferroptosis. European journal of pharmacology, 2025 (PubMed: 40848885) [IF=4.2]
2). ANXA3 as a novel biomarker for sepsis diagnosis: Evidence from integrative WGCNA analysis. Heliyon, 2024 (PubMed: 39430518) [IF=4.0]

Application: IHC    Species: Mouse    Sample: spleen

Fig. 8 The expression level of ANXA3 protein in the spleen (A), lung (B), and liver (C) in septic mice. After 24 h after CLP, the organs were harvested, and abundances of ANXA3 protein were evaluated and quantitated by immunohistochemical staining. ANXA3 was significantly up-regulated in the spleen (A) and significantly down-regulated in the pulmonary vascular endothelium (B) in septic mice. Also, this protein showed few abundances in the liver (C). The CLP operation was utilized to induce sepsis. n = 3 for each group. ∗P < 0.05, ∗∗∗P < 0.001. In 40 × magnification and 200 × magnification, the scale bar represents 500 μm and 100 μm respectively. CLP: Cecal Ligation and Puncture.
3). Gentiopicroside improves DSS-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome. Scientific reports, 2025 (PubMed: 40715435) [IF=3.8]
4). ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury. Molecular immunology, 2024 (PubMed: 38310670) [IF=3.2]

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

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