TAZ Antibody - #DF4653

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製品: TAZ Antibody
カタログ: DF4653
タンパク質の説明: Rabbit polyclonal antibody to TAZ
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 43 KD, 53 kDa; 33kD(Calculated).
ユニプロット: Q16635
RRID: AB_2837004

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
TAZ Antibody detects endogenous levels of total TAZ.
RRID:
AB_2837004
引用形式: Affinity Biosciences Cat# DF4653, RRID:AB_2837004.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Barth syndrome; Cardiomyopathy dilated 3A (X linked); EFE2; Endocardial fibroelastosis 2; Protein G4.5; Tafazzin; TAZ; TAZ protein; TAZ_HUMAN;

免疫原

免疫原:
Uniprot:

Q16635(TAZ_HUMAN) >>Visit HPA database.

遺伝子(ID):
TAZ(6901)
発現特異性:
Q16635 TAZ_HUMAN:

High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

タンパク質配列:
MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQPGR

PTMs - Q16635 基板として

Site PTM Type Enzyme
K56 Ubiquitination
K135 Ubiquitination
K149 Acetylation
K160 Ubiquitination
K264 Ubiquitination

研究背景

機能:

Some isoforms may be involved in cardiolipin (CL) metabolism.

細胞の位置付け:

Membrane>Single-pass membrane protein.

Cytoplasm.

Membrane>Single-pass membrane protein.

Membrane>Single-pass membrane protein.

Membrane>Single-pass membrane protein.

Cytoplasm.

Membrane>Single-pass membrane protein.

Cytoplasm.

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

タンパク質ファミリー:

The hydrophilic domain may serve as an exposed loop interacting with other proteins.

Belongs to the taffazin family.

研究領域

· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.

参考文献

1). Gallic acid from Terminalia chebula inhibited the growth of esophageal carcinoma cells by suppressing the Hippo signal pathway. Iranian Journal of Basic Medical Sciences (PubMed: 33235697) [IF=2.2]
2). FKN regulates macrophage activation in lupus nephritis via the Hippo signaling pathway. Research Square

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