SLC24A1 Antibody - #DF4523
| 製品: | SLC24A1 Antibody |
| カタログ: | DF4523 |
| タンパク質の説明: | Rabbit polyclonal antibody to SLC24A1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 分子量: | 121 KD; 121kD(Calculated). |
| ユニプロット: | O60721 |
| RRID: | AB_2836874 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4523, RRID:AB_2836874.
折りたたみ／展開
CSNB1D; HsT17412; KIAA0702; Na(+)/K(+)/Ca(2+) exchange protein 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; NCKX; NCKX1; NCKX1_HUMAN; Retinal rod Na Ca+K exchanger; Retinal rod Na+/Ca+/K+ exchanger; Retinal rod Na-Ca+K exchanger; RODX; Slc24a1; Sodium/potassium/calcium exchanger 1; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1; Solute carrier family 24 member 1;
免疫原
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
- O60721 NCKX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPSKPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPRGEMKSYSPTQVREKVKYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLKRIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPATSEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVKPTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
PTMs - O60721 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K120 | Acetylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| Y166 | Phosphorylation | Uniprot | |
| T167 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| T189 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| T724 | Phosphorylation | Uniprot | |
| T726 | Phosphorylation | Uniprot | |
| T769 | Phosphorylation | Uniprot |
研究背景
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.
Membrane>Multi-pass membrane protein.
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
研究領域
· Organismal Systems > Sensory system > Phototransduction.
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