製品: SLC5A2 Antibody
カタログ: DF4516
タンパク質の説明: Rabbit polyclonal antibody to SLC5A2
アプリケーション: WB IF/ICC
反応性: Human, Mouse, Rat
予測: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 73 KD(Observed); 73kD(Calculated).
ユニプロット: P31639
RRID: AB_2836867

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Zebrafish(88%), Bovine(89%), Horse(100%), Sheep(89%), Rabbit(89%), Dog(89%)
クローナリティ:
Polyclonal
特異性:
SLC5A2 Antibody detects endogenous levels of total SLC5A2.
RRID:
AB_2836867
引用形式: Affinity Biosciences Cat# DF4516, RRID:AB_2836867.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Low affinity sodium glucose cotransporter; Low affinity sodium-glucose cotransporter; Na(+) glucose cotransporter 2; Na(+)/glucose cotransporter 2; OTTHUMP00000163298; SC5A2_HUMAN; SGLT 2; SLC5A 2; SLC5A2; Sodium glucose cotransporter 2; Sodium/glucose cotransporter 2; Solute carrier family 5 (sodium glucose cotransporter) member 2; Solute carrier family 5 (sodium/glucose transporter), member 2; Solute carrier family 5 member 2;

免疫原

免疫原:

A synthesized peptide derived from human SLC5A2, corresponding to a region within N-terminal amino acids.

Uniprot:
遺伝子(ID):
タンパク質配列:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
89
Sheep
89
Dog
89
Rabbit
89
Zebrafish
88
Xenopus
78
Pig
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

細胞の位置付け:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

参考文献

1). SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na. Molecular and cellular endocrinology, 2024 (PubMed: 38278341) [IF=3.8]

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