| 製品: | DHRS2 Antibody |
| カタログ: | DF3985 |
| タンパク質の説明: | Rabbit polyclonal antibody to DHRS2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 分子量: | 27 KD(Observed); 30kD(Calculated). |
| ユニプロット: | Q13268 |
| RRID: | AB_2836345 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3985, RRID:AB_2836345.
折りたたみ／展開
5430405K24Rik; Dehydrogenase/reductase (SDR family) member 2; Dehydrogenase/reductase member 2; Dehydrogenase/reductase SDR family member 2; Dehydrogenase/reductase SDR family member 2 mitochondria; Dicarbonyl reductase HEP27; Hep27; HEP27 protein; MGC143467; Protein D; SDR family member; SDR25C1; Short chain alcohol dehydrogenase family member; Short chain dehydrogenase/reductase family 25C member 1;
免疫原
A synthesized peptide derived from human DHRS2, corresponding to a region within the internal amino acids.
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
- Q13268 DHRS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL
研究背景
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Mitochondrion matrix. Nucleus.
Note: A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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