MLH3 Antibody - #DF3622
(4)
製品説明
ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IHC 1;200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
反応性:
Human,Mouse,Rat
予測:
Pig(82%), Bovine(91%)
クローナリティ:
Polyclonal
特異性:
MLH3 Antibody detects endogenous levels of total MLH3.
RRID:
AB_2835994
引用形式: Affinity Biosciences Cat# DF3622, RRID:AB_2835994.
引用形式: Affinity Biosciences Cat# DF3622, RRID:AB_2835994.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:
折りたたみ／展開
DNA mismatch repair protein Mlh3; HNPCC 7; HNPCC; HNPCC7; MGC138372; Mismatch repair gene MLH 3; Mismatch repair gene MLH3; MLH 3; MLH3; MLH3_HUMAN; MutL homolog 3 (E. coli); MutL homolog 3; MutL protein homolog 3; S240II117;
免疫原
免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
タンパク質配列:
- Q9UHC1 MLH3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP
種類予測
種類予測:
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
Species
Results
Score
Bovine
91
Pig
82
Horse
73
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UHC1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K128 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| T606 | Phosphorylation | Uniprot | |
| T610 | Phosphorylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| K628 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| K664 | Ubiquitination | Uniprot | |
| Y681 | Phosphorylation | Uniprot | |
| T690 | Phosphorylation | Uniprot | |
| Y691 | Phosphorylation | Uniprot | |
| S746 | Phosphorylation | Uniprot | |
| S753 | Phosphorylation | Uniprot | |
| K876 | Ubiquitination | Uniprot | |
| K881 | Acetylation | Uniprot | |
| S883 | Phosphorylation | Uniprot | |
| K982 | Ubiquitination | Uniprot | |
| T1062 | Phosphorylation | Uniprot | |
| T1128 | Phosphorylation | Uniprot | |
| S1188 | Phosphorylation | Uniprot | |
| T1208 | Phosphorylation | Uniprot | |
| K1243 | Ubiquitination | Uniprot | |
| S1256 | Phosphorylation | Uniprot | |
| S1257 | Phosphorylation | Uniprot | |
| T1258 | Phosphorylation | Uniprot | |
| K1413 | Ubiquitination | Uniprot |
研究背景
機能:
Probably involved in the repair of mismatches in DNA.
細胞の位置付け:
Nucleus.
組織特異性:
Ubiquitous.
サブユニット構造:
Heterodimer of MLH1 and MLH3. Interacts with MTMR15/FAN1.
タンパク質ファミリー:
Belongs to the DNA mismatch repair MutL/HexB family.
研究領域
· Genetic Information Processing > Replication and repair > Mismatch repair.
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