GBP1 Antibody - #DF3598
| 製品: | GBP1 Antibody |
| カタログ: | DF3598 |
| タンパク質の説明: | Rabbit polyclonal antibody to GBP1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Horse, Rabbit |
| 分子量: | 68 KD; 68kD(Calculated). |
| ユニプロット: | P32455 |
| RRID: | AB_2835970 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3598, RRID:AB_2835970.
折りたたみ／展開
GBP 1; GBP-1; GBP1; GBP1_HUMAN; GTP binding protein 1; GTP-binding protein 1; Guanine nucleotide binding protein 1; Guanine nucleotide-binding protein 1; Guanylate binding protein 1; Guanylate binding protein 1 interferon inducible 67kDa; Guanylate binding protein 1 interferon inducible; HuGBP 1; HuGBP-1; HuGBP1; Interferon induced guanylate binding protein 1; Interferon-induced guanylate-binding protein 1; OTTHUMP00000012352;
免疫原
- P32455 GBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P32455 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S52 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| T218 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| Y335 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| Y427 | Phosphorylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| Y464 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| K544 | Methylation | Uniprot | |
| K544 | Ubiquitination | Uniprot | |
| K553 | Acetylation | Uniprot | |
| K562 | Acetylation | Uniprot | |
| K562 | Ubiquitination | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| K582 | Ubiquitination | Uniprot |
研究背景
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Isoprenylation is required for proper subcellular location.
Cytoplasm. Golgi apparatus membrane>Lipid-anchor>Cytoplasmic side. Cell membrane. Secreted.
Note: Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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