Collagen VI alpha 2 Antibody - #DF3552
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF3552, RRID:AB_2835925.
折りたたみ／展開
CO6A2_HUMAN; COL6A2; Collagen alpha 2(VI) chain; Collagen alpha-2(VI) chain; collagen type VI alpha 2; Collagen VI alpha 2 polypeptide; human mRNA for collagen VI alpha 2 C terminal globular domain; PP3610;
免疫原
- P12110 CO6A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQSPTDILLFHMKQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSKGTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEPADPGPPGEPGPRGPRGVPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERIDSLSSFKEAVKNLEWIAGGTWTPSALKFAYDRLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHEKHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQIVCPDLPCQTELSVAQCTQRPVDIVFLLDGSERLGEQNFHKARRFVEQVARRLTLARRDDDPLNARVALLQFGGPGEQQVAFPLSHNLTAIHEALETTQYLNSFSHVGAGVVHAINAIVRSPRGGARRHAELSFVFLTDGVTGNDSLHESAHSMRKQNVVPTVLALGSDVDMDVLTTLSLGDRAAVFHEKDYDSLAQPGFFDRFIRWIC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P12110 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K120 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| N140 | N-Glycosylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| T207 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| Y597 | Phosphorylation | Uniprot | |
| K609 | Acetylation | Uniprot | |
| Y665 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| S685 | Phosphorylation | Uniprot | |
| K688 | Ubiquitination | Uniprot | |
| K692 | Ubiquitination | Uniprot | |
| T701 | Phosphorylation | Uniprot | |
| T703 | Phosphorylation | Uniprot | |
| S705 | Phosphorylation | Uniprot | |
| N785 | N-Glycosylation | Uniprot | |
| K851 | Ubiquitination | Uniprot | |
| N897 | N-Glycosylation | Uniprot | |
| N954 | N-Glycosylation | Uniprot | |
| K1000 | Ubiquitination | Uniprot |
研究背景
Collagen VI acts as a cell-binding protein.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Secreted>Extracellular space>Extracellular matrix. Membrane>Peripheral membrane protein.
Note: Recruited on membranes by CSPG4.
Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI). Interacts with CSPG4.
Belongs to the type VI collagen family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Organismal Systems > Digestive system > Protein digestion and absorption.
参考文献
Application: WB Species: human Sample: ESCC tissues
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