TUSC5 Antibody - #DF3345

(2)  
製品: TUSC5 Antibody
カタログ: DF3345
タンパク質の説明: Rabbit polyclonal antibody to TUSC5
アプリケーション: WB IHC IF/ICC
反応性: Human, Rat
分子量: 22 KD; 19kD(Calculated).
ユニプロット: Q8IXB3
RRID: AB_2835712

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
クローナリティ:
Polyclonal
特異性:
TUSC5 Antibody detects endogenous levels of total TUSC5.
RRID:
AB_2835712
引用形式: Affinity Biosciences Cat# DF3345, RRID:AB_2835712.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Dispanin subfamily B member 1; DSPB1; Interferon-induced transmembrane domain-containing protein D3; LOST1; Protein located at seventeen p thirteen point three 1; Protein located at seventeen-p-thirteen point three 1; Tumor suppressor candidate 5; Tusc5; TUSC5_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human TUSC5, corresponding to a region within N-terminal amino acids.

Uniprot:

Q8IXB3(TARG1_HUMAN) >>Visit HPA database.

遺伝子(ID):
TUSC5(286753)
発現特異性:
Q8IXB3 TARG1_HUMAN:

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).

タンパク質配列:
MAHPVQSEFPSAQEPGSAAFLDLPEMEILLTKAENKDDKTLNLSKTLSGPLDLEQNSQGLPFKAISEGHLEAPLPRSPSRASSRRASSIATTSYAQDQEAPRDYLILAVVACFCPVWPLNLIPLIISIMSRSSMQQGNVDGARRLGRLARLLSITLIIMGIVIIMVAVTVNFTVQKK

研究背景

機能:

Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.

細胞の位置付け:

Cell membrane>Multi-pass membrane protein. Endomembrane system>Multi-pass membrane protein. Cytoplasm>Perinuclear region.
Note: Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. Expressed in adipose tissue.

タンパク質ファミリー:

Belongs to the CD225/Dispanin family.

Restrictive clause

 

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