Parathyroid Hormone Recombinant Rabbit mAb - #BF4368

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製品: Parathyroid Hormone Recombinant Rabbit mAb
カタログ: BF4368
タンパク質の説明: Rabbit monoclonal antibody to Parathyroid Hormone
アプリケーション: WB IHC
反応性: Human
分子量: 12kDa(Observed); 13kD(Calculated).
ユニプロット: P01270

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:200-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23818]
特異性:
Parathyroid Hormone Recombinant Rabbit mAb detects endogenous levels of Parathyroid Hormone.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

hPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Parathyroid hormone; Prepro PTH; Preproparathyroid hormone; PTH; PTH1; PTH1 receptor; PTH1R; PTHR; PTHR1; PTHY_HUMAN;

免疫原

免疫原:

A synthetic peptide from human Parathyroid Hormone

Uniprot:

P01270(PTHY_HUMAN) >>Visit HPA database.

遺伝子(ID):
PTH(5741)
タンパク質の説明:
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone,parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein,known as hyperparathyroidism,can result in hypercalcemia and kidney stones. On the other hand,defective processing of the encoded protein may lead to hypoparathyroidism,which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants.
タンパク質配列:
MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

研究背景

機能:

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the parathyroid hormone family.

Restrictive clause

 

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