TBR1 Recombinant Rabbit mAb - #BF4364

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製品: TBR1 Recombinant Rabbit mAb
カタログ: BF4364
タンパク質の説明: Rabbit monoclonal antibody to TBR1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 74 kDa(Observed); 74kD(Calculated).
ユニプロット: Q16650

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC 1:5000-1:50000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23814]
特異性:
TBR1 Recombinant Rabbit mAb detects endogenous levels of TBR1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

T box brain 1; T box brain protein 1; T brain 1 protein; T-box brain protein 1; T-brain-1; TBR 1; TBR-1; Tbr1; TBR1_HUMAN; TES 56; TES-56;

免疫原

免疫原:

A synthetic peptide from human TBR1

Uniprot:

Q16650(TBR1_HUMAN) >>Visit HPA database.

遺伝子(ID):
TBR1(10716)
発現特異性:
Q16650 TBR1_HUMAN:

Brain.

タンパク質の説明:
This gene is a member of a conserved family of genes that share a common DNA-binding domain,the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse,the ortholog of this gene is expressed in the cerebral cortex,hippocampus,amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse,the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium,calmodulin-dependent serine protein kinase.
タンパク質配列:
MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDISGYYGFYSHS

研究背景

機能:

Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Brain.

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