BMP9 Recombinant Rabbit mAb - #BF4344

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製品: BMP9 Recombinant Rabbit mAb
カタログ: BF4344
タンパク質の説明: Rabbit monoclonal antibody to BMP9
アプリケーション: WB
反応性: Human
分子量: 47 kDa(Observed); 47kD(Calculated).
ユニプロット: Q9UK05

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23794]
特異性:
BMP9 Recombinant Rabbit mAb detects endogenous levels of BMP9.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

BMP 9; Bone morphogenetic protein 9; GDF 2; GDF2; growth differentiation factor 2; Growth/differentiation factor 2; HHT5;

免疫原

免疫原:

A synthetic peptide from human BMP9

Uniprot:

Q9UK05(GDF2_HUMAN) >>Visit HPA database.

遺伝子(ID):
GDF2(2658)
発現特異性:
Q9UK05 GDF2_HUMAN:

Detected in blood plasma (at protein level).

タンパク質の説明:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development,angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia.
タンパク質配列:
MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR

研究背景

機能:

Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.

PTMs:

A reversible disulfide bond can be formed between the two subunits in the homodimer; this has no effect on GDF2 activity.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Detected in blood plasma (at protein level).

タンパク質ファミリー:

Belongs to the TGF-beta family.

Restrictive clause

 

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