FDX1 Recombinant Rabbit mAb - #BF4319

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製品: FDX1 Recombinant Rabbit mAb
カタログ: BF4319
タンパク質の説明: Rabbit monoclonal antibody to FDX1
アプリケーション: WB IF/ICC
反応性: Human, Mouse, Rat
分子量: 14 kDa(Observed); 19kD(Calculated).
ユニプロット: P10109

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23769]
特異性:
FDX1 Recombinant Rabbit mAb detects endogenous levels of FDX1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Adrenal ferredoxin; Adrenodoxin; Adrenodoxin, mitochondrial; ADX; ADX_HUMAN; FDX; fdx1; Ferredoxin 1; Ferredoxin-1; Hepatoredoxin; LOH11CR1D; Mitochondrial adrenodoxin; mitochondrial;

免疫原

免疫原:

A synthetic peptide from human FDX1

Uniprot:

P10109(ADX_HUMAN) >>Visit HPA database.

遺伝子(ID):
FDX1(2230)
発現特異性:
P10109 ADX_HUMAN:

Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level).

タンパク質の説明:
This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450,involved in steroid,vitamin D,and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21.
タンパク質配列:
MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS

研究背景

機能:

Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).

細胞の位置付け:

Mitochondrion matrix.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level).

タンパク質ファミリー:

Belongs to the adrenodoxin/putidaredoxin family.

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