CALB1 Recombinant Rabbit mAb - #BF4256

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製品: CALB1 Recombinant Rabbit mAb
カタログ: BF4256
タンパク質の説明: Rabbit monoclonal antibody to CALB1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 30 kDa(Observed); 30kD(Calculated).
ユニプロット: P05937

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:200-1:1000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23706]
特異性:
CALB1 Recombinant Rabbit mAb detects endogenous levels of CALB1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

avian-type; CAB27; CALB 1; CALB; CALB1; CALB1_HUMAN; Calbindin 1 28kDa; Calbindin; Calbindin D28; D 28K; D-28K; D28K; OTTHUMP00000166027; OTTHUMP00000225441; RTVL H protein; Vitamin D dependent calcium binding protein; Vitamin D dependent calcium binding protein avian type; Vitamin D-dependent calcium-binding protein;

免疫原

免疫原:

A synthetic peptide from human CALB1

Uniprot:

P05937(CALB1_HUMAN) >>Visit HPA database.

遺伝子(ID):
CALB1(793)
タンパク質の説明:
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein,it is now known to be a 28 kDa protein. It contains four active calcium-binding domains,and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease.
タンパク質配列:
MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMALSDGGKLYRTDLALILCAGDN

研究背景

機能:

Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

タンパク質ファミリー:

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Belongs to the calbindin family.

研究領域

· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.

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