PVRL4 Recombinant Rabbit mAb - #BF4241

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製品: PVRL4 Recombinant Rabbit mAb
カタログ: BF4241
タンパク質の説明: Rabbit monoclonal antibody to PVRL4
アプリケーション: WB IHC
反応性: Human
分子量: 40-75 kDa(Observed); 55kD(Calculated).
ユニプロット: Q96NY8

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC: 1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23691]
特異性:
PVRL4 Recombinant Rabbit mAb detects endogenous levels of PVRL4.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

DKFZp686K05193; EDSS1; Ig superfamily receptor LNIR; Nectin 4; Nectin-4; poliovirus receptor-related 4; Processed poliovirus receptor-related protein 4; PRR4; pvrl4; PVRL4_HUMAN;

免疫原

免疫原:

A synthetic peptide from human PVRL4

Uniprot:

Q96NY8(NECT4_HUMAN) >>Visit HPA database.

遺伝子(ID):
NECTIN4(81607)
発現特異性:
Q96NY8 NECT4_HUMAN:

Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

タンパク質の説明:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17,TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1,an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
タンパク質配列:
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

研究背景

機能:

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

(Microbial infection) Acts as a receptor for measles virus.

PTMs:

The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein. Cell junction>Adherens junction.
Note: Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).

Secreted.
Note: The secreted form is found in breast tumor patients (PubMed:15784625).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

タンパク質ファミリー:

Belongs to the nectin family.

研究領域

· Cellular Processes > Cellular community - eukaryotes > Adherens junction.   (View pathway)

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