SNAP23 Recombinant Rabbit mAb - #BF4207

WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Human, Mouse, Rat

Monoclonal [ReFirm23654]

SNAP23 Recombinant Rabbit mAb detects endogenous levels of SNAP23.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

O00161(SNP23_HUMAN) >>Visit HPA database.

O00161 SNP23_HUMAN:

Ubiquitous. Highest levels where found in placenta.

Specificity of vesicular transport is regulated,in part,by the interaction of a vesicle-associated membrane protein termed synaptobrevin,VAMP with a target compartment membrane protein termed syntaxin. These proteins,together with SNAP25 (synaptosome-associated protein of 25 kDa),form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin,VAMP and syntaxin are believed to be involved in vesicular transport in most,if not all cells,while SNAP25 is present almost exclusively in the brain,suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle,target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins,VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

•    O00161 SNP23_HUMAN:
• Protein BLAST With
• NCBI/
• ExPASy/
• Uniprot

MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS