Granzyme B Recombinant Rabbit mAb - #BF4174

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製品: Granzyme B Recombinant Rabbit mAb
カタログ: BF4174
タンパク質の説明: Rabbit monoclonal antibody to Granzyme B
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 28 kDa(Observed);
ユニプロット: P04187

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23621]
特異性:
Granzyme B Recombinant Rabbit mAb detects endogenous levels of Granzyme B.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C11,HLP,CCPI,CGL1,CSPB,SECT,CGL-1,CSP-B,CTLA1,CTSGL1

免疫原

免疫原:

A synthetic peptide from mouse Granzyme B

タンパク質の説明:
This gene encodes a member of the granzyme subfamily of proteins,part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease,which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins,and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.

研究領域

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Type I diabetes mellitus.

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Immune diseases > Autoimmune thyroid disease.

· Human Diseases > Immune diseases > Allograft rejection.

· Human Diseases > Immune diseases > Graft-versus-host disease.

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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