Caveolin 3 Recombinant Rabbit mAb - #BF4113

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製品: Caveolin 3 Recombinant Rabbit mAb
カタログ: BF4113
タンパク質の説明: Rabbit monoclonal antibody to Caveolin 3
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 17 kDa(Observed); 17kD(Calculated).
ユニプロット: P56539

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23560]
特異性:
Caveolin 3 Recombinant Rabbit mAb detects endogenous levels of Caveolin 3.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

LQT9,MPDT,RMD2,VIP21,LGMD1C,VIP-21

免疫原

免疫原:

A synthetic peptide from human Caveolin 3

Uniprot:

P56539(CAV3_HUMAN) >>Visit HPA database.

遺伝子(ID):
CAV3(859)
発現特異性:
P56539 CAV3_HUMAN:

Expressed predominantly in muscle.

タンパク質の説明:
This gene encodes a caveolin family member,which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing,disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C),hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus,with inclusion or exclusion of a differentially spliced intron. In addition,transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
タンパク質配列:
MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

研究背景

機能:

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.

PTMs:

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.

細胞の位置付け:

Golgi apparatus membrane>Peripheral membrane protein. Cell membrane>Peripheral membrane protein. Membrane>Caveola>Peripheral membrane protein. Cell membrane>Sarcolemma.
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed predominantly in muscle.

タンパク質ファミリー:

Belongs to the caveolin family.

研究領域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

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