Cytokeratin 13 Recombinant Rabbit mAb - #BF4066

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製品: Cytokeratin 13 Recombinant Rabbit mAb
カタログ: BF4066
タンパク質の説明: Rabbit monoclonal antibody to Cytokeratin 13
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
分子量: 50 kDa(Observed); 50kD(Calculated).
ユニプロット: P13646

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:5000-1:50000, IHC 1:100-1:200, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse
クローナリティ:
Monoclonal [ReFirm23513]
特異性:
Cytokeratin 13 Recombinant Rabbit mAb detects endogenous levels of Cytokeratin 13.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

K13,CK13,WSN2

免疫原

免疫原:

A synthetic peptide from human Cytokeratin 13

Uniprot:

P13646(K1C13_HUMAN) >>Visit HPA database.

遺伝子(ID):
KRT13(3860)
発現特異性:
P13646 K1C13_HUMAN:

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.

タンパク質の説明:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants,however,not all variants have been described.
タンパク質配列:
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP

研究背景

PTMs:

O-glycosylated; glycans consist of single N-acetylglucosamine residues.

組織特異性:

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.

タンパク質ファミリー:

Belongs to the intermediate filament family.

研究領域

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

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