IFITM1 Recombinant Rabbit mAb - #BF4005

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製品: IFITM1 Recombinant Rabbit mAb
カタログ: BF4005
タンパク質の説明: Rabbit monoclonal antibody to IFITM1
アプリケーション: WB IHC IF/ICC
反応性: Human
分子量: 14 kDa(Observed); 14kD(Calculated).
ユニプロット: P13164

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC 1:200-1:2000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23452]
特異性:
IFITM1 Recombinant Rabbit mAb detects endogenous levels of IFITM1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

9-27,CD225,IFI17,LEU13,DSPA2a

免疫原

免疫原:

A synthetic peptide from human IFITM1

Uniprot:

P13164(IFM1_HUMAN) >>Visit HPA database.

遺伝子(ID):
IFITM1(8519)
発現特異性:
P13164 IFM1_HUMAN:

Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.

タンパク質の説明:
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm,permitting endocytosis,but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses,including influenza A virus,SARS coronavirus (SARS-CoV),Marburg virus (MARV),Ebola virus (EBOV),Dengue virus (DNV),West Nile virus (WNV),human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry,MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration.
タンパク質配列:
MHKEEHEVAVLGPPPSTILPRSTVINIHSETSVPDHVVWSLFNTLFLNWCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGILMTIGFILLLVFGSVTVYHIMLQIIQEKRGY

研究背景

機能:

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.

PTMs:

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.

細胞の位置付け:

Cell membrane>Single-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.

タンパク質ファミリー:

Belongs to the CD225/Dispanin family.

研究領域

· Organismal Systems > Immune system > B cell receptor signaling pathway.   (View pathway)

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