CRABP2 Recombinant Rabbit mAb - #BF3920

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製品: CRABP2 Recombinant Rabbit mAb
カタログ: BF3920
タンパク質の説明: Rabbit monoclonal antibody to CRABP2
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 14 kDa(Observed); 16kD(Calculated).
ユニプロット: P29373

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000, IHC 1:200-1:1000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23367]
特異性:
CRABP2 Recombinant Rabbit mAb detects endogenous levels of CRABP2.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP II; CRABP-II; Crabp2; CRABPII; RABP2_HUMAN; RBP6; Rretinoic acid-binding protein, cellular, type II;

免疫原

免疫原:

A synthetic peptide from human CRABP2

Uniprot:

P29373(RABP2_HUMAN) >>Visit HPA database.

遺伝子(ID):
CRABP2(1382)
タンパク質の説明:
This gene encodes a member of the retinoic acid (RA,a form of vitamin A) binding protein family and lipocalin,cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein,which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway,and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
タンパク質配列:
MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE

研究背景

機能:

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

PTMs:

Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.

細胞の位置付け:

Cytoplasm. Endoplasmic reticulum. Nucleus.
Note: Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Restrictive clause

 

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