CDC6 Recombinant Rabbit mAb - #BF3894

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製品: CDC6 Recombinant Rabbit mAb
カタログ: BF3894
タンパク質の説明: Rabbit monoclonal antibody to CDC6
アプリケーション: WB IHC IF/ICC
反応性: Human
分子量: 63 kDa(Observed); 63kD(Calculated).
ユニプロット: Q99741

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IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:3000, IHC 1:50-1:100, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23341]
特異性:
CDC6 Recombinant Rabbit mAb detects endogenous levels of CDC6.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Cdc 18L; Cdc 6; CDC18 (cell division cycle 18, S.pombe, homolog) like; CDC18 (S.pombe); Cdc18 related protein; CDC18(S.pombe); Cdc18-related protein; Cdc18L; cdc6; CDC6 cell division cycle 6 homolog; CDC6 related protein; CDC6-related protein; CDC6_HUMAN; Cdc6p; CELL CYCLE CONTROLLER CDC6; Cell division control protein 6; Cell division control protein 6 homolog; Cell division cycle 6 homolog (S. cerevisiae); Cell division cycle 6 homolog; Cell division cycle 6, S. cerevisiae, homolog of; HsCDC 6; HsCDC18; HsCDC6; p62; p62(cdc 6); p62(cdc6);

免疫原

免疫原:

A synthetic peptide from human CDC6

Uniprot:

Q99741(CDC6_HUMAN) >>Visit HPA database.

遺伝子(ID):
CDC6(990)
タンパク質の説明:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6,a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1,but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
タンパク質配列:
MPQTRSQAQATISFPKRKLSRALNKAKNSSDAKLEPTNVQTVTCSPRVKALPLSPRKRLGDDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGRRLVFDNQLTIKSPSKRELAKVHQNKILSSVRKSQEITTNSEQRCPLKKESACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREMDVIRNFLREHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIMLNCMSLRTAQAVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRLNQVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKSQTILKPLSECKSPSEPLIPKRVGLIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKEVTLGKLYEAYSKVCRKQQVAAVDQSECLSLSGLLEARGILGLKRNKETRLTKVFFKIEEKEIEHALKDKALIGNILATGLP

研究背景

機能:

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

細胞の位置付け:

Nucleus. Cytoplasm.
Note: The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the CDC6/cdc18 family.

研究領域

· Cellular Processes > Cell growth and death > Cell cycle.   (View pathway)

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