OGG1 Recombinant Rabbit mAb - #BF3835

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製品: OGG1 Recombinant Rabbit mAb
カタログ: BF3835
タンパク質の説明: Rabbit monoclonal antibody to OGG1
アプリケーション: WB
反応性: Human
分子量: 39 kDa(Observed); 39kD(Calculated).
ユニプロット: O15527

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:2000-1:20000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm23282]
特異性:
OGG1 Recombinant Rabbit mAb detects endogenous levels of OGG1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

8 hydroxyguanine DNA glycosylase; 8 oxoguanine DNA glycosylase 1; 8 oxoguanine DNA glycosylase; AP lyase; DNA (apurinic or apyrimidinic site) lyase; DNA apurinic or apyrimidinic site lyase; DNA lyase; DNA-(apurinic or apyrimidinic site) lyase; HMMH; HOGG 1; HOGG1; MMH; MUTM; N glycosylase; Ogg 1; Ogg1; OGG1_HUMAN; OGH 1; OGH1;

免疫原

免疫原:

A synthetic peptide from human OGG1

Uniprot:

O15527(OGG1_HUMAN) >>Visit HPA database.

遺伝子(ID):
OGG1(4968)
発現特異性:
O15527 OGG1_HUMAN:

Ubiquitous.

タンパク質の説明:
This gene encodes the enzyme responsible for the excision of 8-oxoguanine,a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups,type 1 and type 2,depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common,which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described,but the full-length nature for every variant has not been determined.
タンパク質配列:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG

研究背景

機能:

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

細胞の位置付け:

Nucleus>Nucleoplasm. Nucleus speckle. Nucleus matrix.
Note: Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.

Nucleus.

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous.

タンパク質ファミリー:

Belongs to the type-1 OGG1 family.

研究領域

· Genetic Information Processing > Replication and repair > Base excision repair.

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