SERPINH1 Recombinant Rabbit mAb - #BF3828

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製品: SERPINH1 Recombinant Rabbit mAb
カタログ: BF3828
タンパク質の説明: Rabbit monoclonal antibody to SERPINH1
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 46 kDa(Observed); 46kD(Calculated).
ユニプロット: P50454

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IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:100-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23275]
特異性:
SERPINH1 Recombinant Rabbit mAb detects endogenous levels of SERPINH1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

47 kDa heat shock protein; 47 kDa heat shock protein precursor; Arsenic transactivated protein 3; Arsenic-transactivated protein 3; AsTP 3; AsTP3; CBP 1; CBP 2; CBP1; CBP2; Cell proliferation-inducing gene 14 protein; Collagen binding protein 1; Collagen binding protein 2; Collagen binding protein; Collagen-binding protein 2; Collagen-binding protein; Colligen; Colligin 1; Colligin 2; Colligin; colligin-1; colligin-2; gp46; Heat shock protein 47; Heat-shock protein 47; HGNC 1547; Hsp 47; J6; OI10; PIG 14; PIG14; PPROM; Proliferation inducing gene 14; Proliferation inducing gene 14 protein; RA A47; RA-A47; Rheumatoid arthritis antigen A 47; rheumatoid arthritis antigen A-47; Rheumatoid arthritis related antigen RA A47; Rheumatoid arthritis-related antigen RA-A47; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2); Serine or cysteine proteinase inhibitor clade H member 1; Serine or cysteine proteinase inhibitor clade H member 2; SERPH_HUMAN; Serpin H1; Serpin peptidase inhibitor clade H member 1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Serpin peptidase inhibitor, clade H, member 1; SERPINH1; SERPINH2;

免疫原

免疫原:

A synthetic peptide from human SERPINH1

Uniprot:

P50454(SERPH_HUMAN) >>Visit HPA database.

遺伝子(ID):
SERPINH1(871)
タンパク質の説明:
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer,and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene,and a pseudogene of this gene is located on the short arm of chromosome 9.
タンパク質配列:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL

研究背景

機能:

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

細胞の位置付け:

Endoplasmic reticulum lumen.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the serpin family.

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