FXR1 Recombinant Rabbit mAb - #BF3709

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製品: FXR1 Recombinant Rabbit mAb
カタログ: BF3709
タンパク質の説明: Rabbit monoclonal antibody to FXR1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 70-80,82-84 kDa(Observed); 70kD(Calculated).
ユニプロット: P51114

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説明書
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IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000, IHC 1:100-1:200, IF/ICC 1:200-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm23156]
特異性:
FXR1 Recombinant Rabbit mAb detects endogenous levels of FXR1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Fragile X mental retardation autosomal homolog 1; Fragile X mental retardation syndrome related protein 1; Fragile X mental retardation syndrome-related protein 1; FXR1; FXR1_HUMAN; FXR1P; hFXR1p;

免疫原

免疫原:

A synthetic peptide from human FXR1

Uniprot:

P51114(FXR1_HUMAN) >>Visit HPA database.

遺伝子(ID):
FXR1(8087)
発現特異性:
P51114 FXR1_HUMAN:

Expressed in all tissues examined including heart, brain, kidney and testis.

タンパク質の説明:
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes,predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
タンパク質配列:
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS

研究背景

機能:

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).

PTMs:

Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

細胞の位置付け:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in all tissues examined including heart, brain, kidney and testis.

タンパク質ファミリー:

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.

Belongs to the FMR1 family.

研究領域

· Genetic Information Processing > Translation > RNA transport.

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