TSG6 Recombinant Rabbit mAb - #BF3547

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製品: TSG6 Recombinant Rabbit mAb
カタログ: BF3547
タンパク質の説明: Rabbit monoclonal antibody to TSG6
アプリケーション: WB
反応性: Human, Mouse, Rat
分子量: 35-38 kDa(Observed); 31kD(Calculated).
ユニプロット: P98066

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IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Monoclonal [ReFirm22994]
特異性:
TSG6 Recombinant Rabbit mAb detects endogenous levels of TSG6.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Hyaluronate binding protein; Hyaluronate-binding protein; TNF alpha induced protein 6; TNF alpha-induced protein 6; TNF stimulated gene 6 protein; TNF-stimulated gene 6 protein; TNFAIP 6; Tnfaip6; TSG 6; TSG-6; TSG6_HUMAN; Tumor necrosis factor alpha induced protein 6; Tumor necrosis factor alpha inducible protein 6; Tumor necrosis factor alpha-induced protein 6; Tumor necrosis factor inducible gene 6 protein; Tumor necrosis factor stimulated gene 6 protein; Tumor necrosis factor-inducible gene 6 protein;

免疫原

免疫原:

A synthetic peptide from human TSG6

Uniprot:

P98066(TSG6_HUMAN) >>Visit HPA database.

遺伝子(ID):
TNFAIP6(7130)
発現特異性:
P98066 TSG6_HUMAN:

Found in the synovial fluid of patients with rheumatoid arthritis.

タンパク質の説明:
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain,and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I),and thus enhance the serine protease inhibitory activity of I alpha I,which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.
タンパク質配列:
MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL

研究背景

機能:

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

組織特異性:

Found in the synovial fluid of patients with rheumatoid arthritis.

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