HAMP Recombinant Rabbit mAb - #BF3309

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製品: HAMP Recombinant Rabbit mAb
カタログ: BF3309
タンパク質の説明: Rabbit monoclonal antibody to HAMP
アプリケーション: WB
反応性: Human, Rat
分子量: 9,3 kDa(Observed); 9kD(Calculated).
ユニプロット: P81172

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Rat
クローナリティ:
Monoclonal [ReFirm22756]
特異性:
HAMP Recombinant Rabbit mAb detects endogenous levels of HAMP.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Hamp; HEPC; HEPC_HUMAN; Hepc20; Hepc25; Hepcidin-20; HFE2B; LEAP-1; LEAP1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor;

免疫原

免疫原:

A synthetic peptide from human HAMP

Uniprot:

P81172(HEPC_HUMAN) >>Visit HPA database.

遺伝子(ID):
HAMP(57817)
発現特異性:
P81172 HEPC_HUMAN:

Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.

タンパク質の説明:
The product encoded by this gene is involved in the maintenance of iron homeostasis,and it is necessary for the regulation of iron storage in macrophages,and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20,22 and 25 amino acids,and these active peptides are rich in cysteines,which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B,also known as juvenile hemochromatosis,a disease caused by severe iron overload that results in cardiomyopathy,cirrhosis,and endocrine failure.
タンパク質配列:
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT

研究背景

機能:

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.

タンパク質ファミリー:

Belongs to the hepcidin family.

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