Osteocalcin Recombinant Rabbit mAb - #BF3051

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製品: Osteocalcin Recombinant Rabbit mAb
カタログ: BF3051
タンパク質の説明: Rabbit monoclonal antibody to Osteocalcin
アプリケーション: WB
反応性: Human
分子量: 11 kDa(Observed); 11kD(Calculated).
ユニプロット: P02818

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製品説明

ソース:
Rabbit IgG
アプリケーション:
WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [ReFirm22498]
特異性:
Osteocalcin Recombinant Rabbit mAb detects endogenous levels of Osteocalcin.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

BGLAP; BGP; Bone gamma carboxyglutamate (gla) protein; Bone gamma carboxyglutamate gla protein osteocalcin; Bone gamma carboxyglutamate protein; Bone Gla protein; Gamma carboxyglutamic acid containing protein; Gamma-carboxyglutamic acid-containing protein; OC; OCN; OSTCN_HUMAN; Osteocalcin; OTTHUMP00000016586; PMF1;

免疫原

免疫原:

A synthetic peptide from human Osteocalcin

Uniprot:

P02818(OSTCN_HUMAN) >>Visit HPA database.

遺伝子(ID):
BGLAP(632)
タンパク質の説明:
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain,which functions in binding to calcium and hydroxyapatite,the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene,PMF1 (polyamine-modulated factor 1),but the encoded protein only shows sequence identity with the upstream gene product.
タンパク質配列:
MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV

研究背景

機能:

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

PTMs:

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the osteocalcin/matrix Gla protein family.

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