AFfirm™ KLRC2/4 Mouse Monoclonal Antibody - #BF9419

製品: KLRC2/4 Mouse Monoclonal Antibody
カタログ: BF9419
タンパク質の説明: Mouse monoclonal antibody to KLRC2/4
アプリケーション: WB
反応性: Human
予測: Mouse, Rat
分子量: 18 kDa; 26kD,18kD(Calculated).
ユニプロット: P26717 | O43908

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm9419]
特異性:
KLRC2/4 Mouse Monoclonal Antibody detects endogenous levels of total KLRC2/4.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD antigen CD159c; CD159 antigen like family member C; CD159 antigen-like family member C; CD159c; Killer cell lectin like receptor subfamily C, member 2; KLRC2; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2-C-activating NK receptor; NKG2C activating NK receptor; NKG2C; NKG2C_HUMAN; killer cell lectin-like receptor subfamily C, member 4; KLRC4; NK cell receptor F; NKG2 F; NKG2-F type II integral membrane protein; NKG2-F-activating NK receptor; NKG2F; NKG2F_HUMAN;

免疫原

免疫原:
Uniprot:

P26717(NKG2C_HUMAN) >>Visit HPA database.

O43908(NKG2F_HUMAN) >>Visit HPA database.

遺伝子(ID):
KLRC2(3822) | KLRC4(8302)
発現特異性:
P26717 NKG2C_HUMAN:

Natural killer cells.

O43908 NKG2F_HUMAN:

Natural killer cells.

タンパク質配列:
MSKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL

MNKQRGTYSEVSLAQDPKRQQRKLKGNKISISGTKQEIFQVELNLQNASSDHQGNDKTYHCKGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPCIGVLEQNNFSLNRRMQKARHCGHCPEEWITYSNSCYYIGKERRTWEERVCWPVLRRTLICFL

PTMs - P26717/O43908 基板として

Site PTM Type Enzyme
S32 Phosphorylation

研究背景

機能:

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

細胞の位置付け:

Membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Natural killer cells.

サブユニット構造:

Can form disulfide-bonded heterodimer with KLRD1. Interacts with TYROBP. KLRD1-KLRC2 receptor complex can bind with low affinity to peptide-bound HLA-E-B2M complex.

機能:

May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

細胞の位置付け:

Membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Natural killer cells.

サブユニット構造:

Can form disulfide-bonded heterodimer with CD94.

研究領域

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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