AFfirm™ EDG7 Mouse Monoclonal Antibody - #BF9370
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Calcium mobilizing lysophosphatidic acid receptor LP A3; Calcium mobilizing lysophosphatidic acid receptor LPA 3; Calcium mobilizing lysophosphatidic acid receptor LPA3; EDG 7; Endothelial cell differentiation gene 7; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 7; FLJ98231; GPCR; HOFNH 30; HOFNH30; LP A3; LPA 3; LPA receptor 3; LPA receptor EDG 7; LPA receptor EDG7; LPA-3; LPA3; LPAR 3; Lpar3; LPAR3_HUMAN; Lysophosphatidic acid receptor 3; Lysophosphatidic acid receptor Edg 7; Lysophosphatidic acid receptor Edg-7; Lysophosphatidic acid receptor Edg7; OTTHUMP00000011573; RP4 678I3; RP4678I3;
免疫原
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
- Q9UBY5 LPAR3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
PTMs - Q9UBY5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T118 | Phosphorylation | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot |
研究背景
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Cell membrane>Multi-pass membrane protein.
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
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