AFfirm™ EFNB2 Mouse Monoclonal Antibody - #BF8156
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
EFN B2; EFNB 2; Efnb2; EFNB2_HUMAN; Eph related receptor tyrosine kinase ligand 5; EPH-related receptor tyrosine kinase ligand 5; ephrin B2; Ephrin-B2; EphrinB2; EPLG 5; EPLG5; Htk L; HTK ligand; HTK-L; HTKL; LERK 5; LERK-5; LERK5; Ligand of eph related kinase 5; MGC126226; MGC126227; MGC126228; OTTMUSP00000024973;
免疫原
- P52799 EFNB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
PTMs - P52799 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y11 | Phosphorylation | Uniprot | |
| N36 | N-Glycosylation | Uniprot | |
| T69 | Phosphorylation | Uniprot | |
| T180 | O-Glycosylation | Uniprot | |
| T189 | O-Glycosylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| T264 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| Y304 | Phosphorylation | P29323 (EPHB2) | Uniprot |
| S308 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| Y316 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| Y330 | Phosphorylation | Uniprot | |
| Y331 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot |
研究背景
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Cell membrane>Single-pass type I membrane protein. Cell junction>Adherens junction.
Lung and kidney.
Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3.
(Microbial infection) Interacts with Hendra virus and Nipah virus G protein.
Belongs to the ephrin family.
研究領域
· Organismal Systems > Development > Axon guidance. (View pathway)
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