AFfirm™ FN3K Mouse Monoclonal Antibody - #BF8088
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
2310074G21Rik; Fnsk; Fructosamine 3 kinase; RP23-293H17.4;
免疫原
- Q9H479 FN3K_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK
PTMs - Q9H479 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| C24 | S-Nitrosylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| Y296 | Phosphorylation | Uniprot | |
| S298 | Phosphorylation | Uniprot |
研究背景
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines.
Widely expressed. Expressed in erythrocytes.
Monomer.
Belongs to the fructosamine kinase family.
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