AFfirm™ RanBP1 Mouse Monoclonal Antibody - #BF8086
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
HTF9A; RAN binding protein 1; Ran specific GTPase activating protein; Ran-binding protein 1; Ran-specific GTPase-activating protein; RANBP1; RANG_HUMAN;
免疫原
- P43487 RANG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAKDTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGAIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKAGSGKNDHAEKVAEKLEALSVKEETKEDAEEKQ
PTMs - P43487 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K5 | Acetylation | Uniprot | |
| T7 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| T15 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K54 | Acetylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| K68 | Acetylation | Uniprot | |
| K68 | Methylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| K79 | Acetylation | Uniprot | |
| Y103 | Phosphorylation | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| K111 | Acetylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K150 | Acetylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K152 | Acetylation | Uniprot | |
| K154 | Acetylation | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K160 | Acetylation | Uniprot | |
| K183 | Acetylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K190 | Acetylation | Uniprot | |
| K190 | Sumoylation | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| T193 | Phosphorylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| K200 | Acetylation | Uniprot |
研究背景
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP.
Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (By similarity). Identified in a complex with nucleotide-free RAN and RCC1.
Belongs to the RANBP1 family.
研究領域
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.